The live webcast may be accessed through the Company’s website at www.anci-care.com under “News & Events.” The webcast will be archived for 90 days.

DALLAS, TX – November 13, 2008 -- American CareSource Holdings, Inc. (Nasdaq: ANCI) today announced record financial and operational results for the three and nine months ended September 30, 2008.  Recent highlights include:
• Reported quarterly net income of $1.0 million, or $0.06 per diluted share, resulting in five consecutive quarters of profit growth.
• Achieved $16.1 million in revenue for the third quarter, a 127% increase in revenues compared to the same prior year period, representing six quarters of sequential revenue growth.

Dallas, TX, November 4, 2008 – American CareSource Holdings, Inc. (Nasdaq: ANCI) announced today that it will hold a conference call on November 13, 2008 to discuss financial results for the third quarter and nine months ended September 30, 2008. David S. Boone, Chief Executive Officer, and Steven J. Armond, Chief Financial Officer, of American CareSource will host the call. 

Access information
Date:   Thursday, November 13, 2008
Time:   10:00 a.m. (CT)/11:00 a.m. (ET)
Dial-in numbers: 877-856-1956 (U.S. & Canada) or 719-325-4818
Live webcast:  www.anci-care.com, under “News & Events”

The live webcast may be accessed through the Company’s website at www.anci-care.com under “News & Events.” The webcast will be archived for 90 days.

DALLAS, TX – October 22, 2008 -- American CareSource Holdings, Inc. (Nasdaq: ANCI) today reported a 127% increase in revenues to approximately $16.1 million for the third quarter ended September 30, 2008 compared to approximately $7.1 million in the same period last year.  The Company’s third quarter revenues also represent a 24% improvement over second quarter 2008 reported revenues of $13.0 million.  For the nine months ended September 30, 2008, the Company reported a 204% improvement in revenues to approximately $40.6 million compared to the same period in 2007.

Dallas, TX, September 30, 2008 – American CareSource Holdings, Inc. (Nasdaq: ANCI) announced today that its Chief Executive Officer, David S. Boone, will present at the William Blair & Company Second Annual Small-Cap Growth Stock Conference at 2:00 p.m. ET on October 7, 2008 at The Waldorf-Astoria Hotel in New York City.

The live webcast may be accessed through the Company’s website at www.anci-care.com under “News & Events.” The webcast will be archived for 90 days.

About Ancillary Healthcare Services

American CareSource provides ancillary healthcare services through its network that offers cost effective alternatives to physician and hospital-based services. This market is estimated at $574 billion, and has grown to 30% of total national health expenditures. These providers offer services in over 30 categories, including laboratories, dialysis centers, free-standing diagnostic imaging centers, non-hospital surgery centers, as well as durable medical equipment such as orthotics and prosthetics, and others.

About American CareSource Holdings, Inc. 

American CareSource Holdings, the first national, publicly traded ancillary care network services company, offers a comprehensive national network of approximately 2,500 ancillary service providers at over 25,000 sites. The Company's ancillary network and management provides a complete outsourced solution for a wide variety of healthcare payors and plan sponsors including self-insured employers, indemnity insurers, PPOs, HMOs, third party administrators and both federal and local governments. For additional information, please visit www.anci-care.com.

Dallas, TX, September 29, 2008 – American CareSource Holdings, Inc. (Nasdaq: ANCI) announced today that its Chief Executive Officer, David S. Boone, will present at the Third Annual JMP Securities Healthcare Focus Conference at 2:00 p.m. ET on October 6, 2008 at the Le Parker Meridien in New York City.

The live webcast may be accessed through the Company’s website at www.anci-care.com under “News & Events.” The webcast will be archived for 90 days.

About Ancillary Healthcare Services

American CareSource provides ancillary healthcare services through its network that offers cost effective alternatives to physician and hospital-based services. This market is estimated at $574 billion, and has grown to 30% of total national health expenditures. These providers offer services in over 30 categories, including laboratories, dialysis centers, free-standing diagnostic imaging centers, non-hospital surgery centers, as well as durable medical equipment such as orthotics and prosthetics, and others.

About American CareSource Holdings, Inc. 

American CareSource Holdings, the first national, publicly traded ancillary care network services company, offers a comprehensive national network of approximately 2,500 ancillary service providers at over 25,000 sites. The Company's ancillary network and management provides a complete outsourced solution for a wide variety of healthcare payors and plan sponsors including self-insured employers, indemnity insurers, PPOs, HMOs, third party administrators and both federal and local governments. For additional information, please visit www.anci-care.com.

American CareSource to Provide Ancillary Care Services to Key JMS Client, Insurance Design Administrators

DALLAS, TX – September 29, 2008  -- American CareSource Holdings, Inc. (Nasdaq: ANCI) announced today that it has signed a new client service contract with JMS and Associates, Inc., to provide a full range of ancillary care services, initially to one of JMS’ key clients, Insurance Design Administrators (IDA).  JMS provides Business Process Outsourcing (BPO) solutions including Paper Claim Conversion Services to TPAs, HMOs, PPOs, Health Plans, MHOs and Cost Containment organizations supporting the Health Claim Payor industry.  IDA is a recognized, national leader in the design and administration of self-funded health benefits plans for employers and government agencies across the United States and is a subsidiary of UHY, one of the world’s leading business advisory, consulting and accounting networks.

- Company reports fourth consecutive quarterly profit of $621 thousand, or $0.04 per diluted share -

DALLAS, TX – August 14, 2008 -- American CareSource Holdings, Inc. (AMEX: XSI) today announced record financial and operational results for the second quarter and six months ended June 30, 2008.  Highlights include:

• Reported quarterly net income of $621 thousand, or $0.04 per diluted share, resulting in four consecutive quarters of profit growth.

• Achieved $13.0 million in revenue for the second quarter, a record 225% increase in revenues compared to the same prior year period, representing five quarters of sequential revenue growth.

• Attained gross margins of approximately 15% compared to 13% in the three months ended June 30, 2007, reflecting continued leverage of the Company’s fixed cost infrastructure.

• Generated EBITDA, as adjusted, of approximately $879 thousand for the quarter.
− EBITDA, as adjusted, (a non-GAAP measure) is defined as income (loss) from operations less depreciation and amortization, non-cash warrant and option compensation expense and executive severance. EBITDA, as adjusted, should be considered in addition to, but not in lieu of, income (loss) from operations reported under generally accepted accounting principles (GAAP).

• The Company finished the quarter with approximately $6.1 million in cash and cash equivalents on hand and generated approximately $500 thousand in cash from operating activities in the second quarter and approximately $2.1 million during the first half of 2008.

• Claims volume increased to approximately 40 thousand for the second quarter of 2008, up 172% over the second quarter of 2007.

• Signed new client agreements with Viant Holdings, Inc., one of the nation’s largest PPO networks, and Emerald Health Network, Ohio’s premiere PPO network provider.

• Signed two new client agreements with Indiana-based union organizations allowing the Company to penetrate an important union market in the Midwest.

• Selected to join the Russell Microcap® Index.

Commenting on today’s announcement, David S. Boone, Chief Executive Officer of American CareSource, stated, “Our second quarter results demonstrate a continuation of the strong momentum we are building in the market place.  With these results, we have generated four consecutive quarters of greater than 100% year-over-year revenue growth and delivered four consecutive quarters of increasing profitability.  We finished the quarter with over $6 million in cash and we continue to generate strong cash flow.  Our investments in technology and people are beginning to pay dividends.  Most importantly, our recent client wins are yet another confirmation of the value we are adding to our clients and providers as we work to lower the cost of ancillary healthcare.

“We are achieving the goals we have set for the organization including delivering improved gross margins.  The Company is demonstrating its ability to scale effectively by absorbing the increasing claim volume without a corresponding increase in cost.  Demand for our comprehensive and expanding national network of ancillary healthcare services has continued, unabated and our reputation for being able to offer clients an ever-increasing range of services with positive economics should fuel this upward momentum going forward. As a result, we are raising our initial 2008 guidance of $50 million in annual revenues to a range of $50 - $55 million for the year.
 
“Reflecting our growth, during the second quarter, we were pleased to announce new client agreements with Viant Holdings, one of the largest PPO networks in the United States, as well as Emerald Health Networks, Ohio’s premier PPO network provider. Additionally, we gained a foothold into the all-important Midwest union market with the signing of two new client agreements with Iron Workers Local 295 Trust Fund and Operative Plasterers and Cement Masons Local 692. We are honored to be working with these two, key union organizations and, in addition to our more traditional clientele, hope to sign similar agreements with other unions as time goes on.”

Revenues for the second quarter of 2008 rose 225% to $13.0 million compared to $4.0 million in the second quarter of 2007. The Company’s second quarter revenues also represent a 13% improvement over the first quarter of 2008 reported revenues of $11.5 million. For the six months ended June 30, 2008, the Company reported revenues of $24.5 million, a 291% increase compared to revenues of $6.3 million in the same period of 2007.

The Company reported net income of $621 thousand, or $0.04 per share, for the three months ended June 30, 2008, compared to a net loss of $716 thousand, or ($0.05) per share, in the same period last year. For the six months ended June 30, 2008, the Company reported net income of $1.1 million, or $0.07 per diluted share, compared to a net loss of $1.3 million, or ($0.09) per share, for the same period in 2007.

Cash provided by operations was $2.1 million for the six months ended June 30, 2008 versus cash used in operations of ($1.1) million during the same period in 2008. Factors affecting the improvement in operating cash flows include earnings growth, accelerated client collections and overall effectiveness in working capital management.  At June 30, 2008, the Company had approximately $6.1 million in cash and cash equivalents compared to $4.3 million at December 31, 2007.

Conference Call
As previously announced, American CareSource will hold a conference call to discuss financial results of the second quarter ended June 30, 2008 as follows:

Date: Thursday, August 14, 2008
Time: 10:00 a.m. (CT)/11:00 a.m. (ET)
Dial-in numbers: 877-397-0286 (U.S. & Canada) or 719-325-4874
Live webcast: www.anci-care.com, under “New & Events”

The teleconference replay will be available two hours after completion through Thursday, August 21, 2008 at 888-203-1112 (U.S. & Canada) or 719-457-0820. The replay pass code is 3692642. The archived webcast will be available for one year on the Company’s investor website, www.anci-care.com, under “News and Events.”

About Ancillary Healthcare Services
American CareSource provides ancillary healthcare services through its network that offers cost effective alternatives to physician and hospital-based services. This market is estimated at $574 billion, and has grown to 30% of total national health expenditures. These providers offer services in over 30 categories, including laboratories, dialysis centers, free-standing diagnostic imaging centers, non-hospital surgery centers, as well as durable medical equipment such as orthotics and prosthetics, and others.

About American CareSource Holdings, Inc. 

American CareSource Holdings, the first national, publicly traded ancillary care network services company, offers a comprehensive national network of approximately 2,500 ancillary service providers at over 25,000 sites. The Company's ancillary network and management provides a complete outsourced solution for a wide variety of healthcare payors and plan sponsors including self-insured employers, indemnity insurers, PPOs, HMOs, third party administrators and both federal and local governments. For additional information, please visit www.anci-care.com.

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995:
Any statements that are not historical facts contained in this release, including with respect to future engagements by clients, revenue growth, earnings, and guidance are forward-looking statements. It is possible that the assumptions made by American CareSource Holdings, Inc. for purposes of such statements may prove to be inaccurate or may not materialize. Actual results may differ materially from those projected or implied in any forward-looking statements. Such statements may involve further risks and uncertainties, including but not limited to those relating to demand for our services, pricing, market acceptance, our ability to integrate with our clients, our ability to attract and maintain providers, our ability to manage growth, the effect of economic conditions, and the affect of competitive services, risks in product development, the ability to complete transactions, and other risks identified in this release, and the Securities and Exchange Commission filings of American CareSource Holdings, Inc.

(See More for Revenue Tables)

Mr. Boone will give a 23-minute presentation regarding American CareSource’s market positioning, financial performance, and strategic direction. A live webcast may be accessed through the Company’s website at www.anci-care.com under “News & Events.” The webcast will be archived for 30 days.

About American CareSource Holdings, Inc. 

American CareSource Holdings, the first national, publicly traded ancillary care network services company offers a comprehensive national network of approximately 2,500 ancillary service providers at over 25,000 sites. The Company's ancillary network and management provides a complete outsourced solution for a wide variety of healthcare payors and plan sponsors including self-insured employers, indemnity insurers, PPOs, HMOs, third party administrators and both federal and local governments. For additional information, please visit www.anci-care.com.

A live webcast can be accessed through the Company’s website.

The webcast will be archived for 30 days.

About American CareSource Holdings, Inc.
American CareSource Holdings, the first national, publicly traded ancillary care network services company offers a comprehensive national network of approximately 2,500 ancillary service providers at over 25,000 sites. The Company's ancillary network and management provides a complete outsourced solution for a wide variety of healthcare payors and plan sponsors including self-insured employers, indemnity insurers, PPOs, HMOs, third party administrators and both federal and local governments. For additional information, please visit www.anci-care.com.

Company Expands its Reach in the Midwest

DALLAS, TX – June 4, 2008 -- American CareSource Holdings, Inc. (AMEX: XSI) announced today it has signed a new agreement with Emerald Health Network (EHN) to provide ancillary care services to EHN’s Preferred Provider Organization (PPO) and payor client base. Emerald Health Network is one of Ohio’s premier PPO networks and has served as a leading healthcare solutions company for both the employer and provider communities since 1983.

- Company reports third consecutive quarterly profit of $521 thousand, or $0.03 per share -

DALLAS, TX – May 15, 2008 -- American CareSource Holdings, Inc. (AMEX: XSI) today announced record financial and operational results for the first quarter ended March 31, 2008.

Access information
Date:   Thursday, May 15, 2008
Time:   10:00 a.m. (CT)/11:00 a.m. (ET)
Dial-in numbers: 877-675-4757 (U.S. & Canada) or 719-325-4911
Live webcast:  www.anci-care.com, under “New & Events”

DALLAS, TX – March 31, 2008 -- American CareSource Holdings, Inc. (AMEX: XSI) today announced record financial and operational results for the fourth quarter and year ended December 31, 2007.  Highlights include:
• Reported a quarterly profit of $319 thousand in net income, or $0.02 per share – the largest profit in the Company’s history.
• Achieved $10.1 million in revenue for the quarter, a record 260% rise in revenues for Q4 2007 compared to Q4 2006.
• Achieved $23.5 million in revenue for the year, a 106% increase in revenues for 2007 compared to 2006.
• Generated EBITDA, as adjusted, of $222 thousand for the quarter and $(85) thousand for the year.
− EBITDA, as adjusted, (a non-GAAP measure) is defined as income (loss) from operations less depreciation and amortization, non-cash warrant and option compensation expense and executive severance. EBITDA, as adjusted, should be considered in addition to, but not in lieu of, income (loss) from operations reported under generally accepted accounting principles (GAAP).
• The Company finished the year with $4.3 million in cash on hand and generated $687 thousand in cash from operating activities in the fourth quarter.
• Claims volume increased to 51,039 for Q4 2007, up 243% over Q4 2006.
• Recent key executive additions:
− Cornelia Outten appointed to Vice President of Network Development
− Rost A. Ginevich named Chief Information Officer

Commenting on today’s announcement, David S. Boone, Chief Executive Officer of American CareSource, stated, “We are delighted to report such strong financial results for the fourth quarter and year ended December 31, 2007.  We worked diligently during the past year to make the transition from a network provider to an ancillary services provider that works in true partnership with its clients, and I am pleased to say that we achieved this goal. As a result, we were successful in adding new clients while expanding many of our existing client relationships. This has translated into a greater than tripling of revenues for the fourth quarter of 2007 compared to 2006 and a substantial increase in claims volume for the period.

“Our continued growth has necessitated an expansion of the management team.  In February 2008, Cornelia Outten was appointed to the position of Vice President of Network Development and, just recently, Rost Ginevich joined the Company in the newly created position of Chief Information Officer.  Cornelia and Rost each bring to American CareSource over 20 years of experience in their fields of expertise and are already contributing greatly to our growth goals.”

Revenues for the fourth quarter of 2007 rose 260% to $10.1 million compared to $2.8 million in the fourth quarter of 2006. For the year ended December 31, 2007, the Company reported revenues of $23.5 million, a 106% increase compared to revenues of $11.4 million in the same period of 2006.

The Company reported net income of $319 thousand, or $0.02 per share, for the fourth quarter of 2007, compared to a net loss of $673 thousand, or $0.04 per share, in the same period last year. Factors affecting positive current quarter results include increases in revenue from Texas True Choice and HealthSmart, and the implementation of American Administrative Group (AAG) and two other clients.

For the year ended December 31, 2007, the Company reported a net loss of $820 thousand, or $0.06 per share, compared to a net loss of $1.3 million, or $0.09 per share, for the same period in 2006. Excluding the one time charge for the departure of the Company’s former Chief Executive Officer, the net loss for the year ended December 31, 2007 was $490 thousand.

Cash provided by operations was $687 thousand in the fourth quarter of 2007 versus $38 thousand in the fourth quarter of 2006. At December 31, 2007, the Company had $4.3 million in cash and cash equivalents compared to $5.0 million at December 31, 2006.

Date: Monday, March 31, 2008
Time: 11:00 AM ET/10:00 AM CT
Dial-in numbers: 877-627-6544 (U.S. & Canada) or 719-325-4918
Live webcast: www.anci-care.com, under “News and Events”

The teleconference replay will be available two hours after completion through Monday, April 7, 2008 at 888-203-1112 (U.S. only) or 719-457-0820. The replay pass code is 6401182. The archived webcast will be available for one year on the Company’s investor website, www.anci-care.com, under “News and Events.”

About American CareSource Holdings, Inc.
American CareSource Holdings, the first national, publicly traded ancillary care network services company, offers a comprehensive national network of more than 25,000 ancillary provider sites. Through its product offerings, American CareSource helps its clients reduce the cost of ancillary services rendered through its network of providers in more than 30 service categories. The Company’s ancillary network and management provides a complete outsourced solution for a wide variety of healthcare payors and plan sponsors including self-insured employers, indemnity insurers, PPOs, HMOs, third party administrators and both federal and local governments.

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995:

Any statements that are not historical facts contained in this release are forward-looking statements. It is possible that the assumptions made by American CareSource Holdings, Inc. for purposes of such statements may not materialize. Actual results may differ materially from those projected or implied in any forward-looking statements. Such statements may involve further risks and uncertainties, including but not limited to those relating to product demand, pricing, market acceptance, the effect of economic conditions, and intellectual property rights, and the outcome of competitive products, risks in product development, the ability to complete transactions, and other risks identified in this release, and the Securities and Exchange Commission filings of American CareSource Holdings, Inc.

Dallas, TX, March 17, 2008 – American CareSource Holdings, Inc. (AMEX: XSI) announced today that it will hold a conference call on March 31, 2008 to discuss financial results for the fourth quarter and year ended December 31, 2007. David S. Boone, Chief Executive Officer, and Steven J. Armond, Chief Financial Officer, of American CareSource will host the call.

Live webcast will be available here for one year after the conference call.  The teleconference replay will be available two hours after completion through Monday, April 7, 2008 at 888-203-1112 (U.S. only) or 719- 457-0820. The replay passcode is 6401182.

DALLAS, TX – February 19, 2008 -- American CareSource Holdings, Inc. (AMEX: XSI) today reported a 260% increase in revenues to approximately $10.1 million for the fourth quarter ended December 31, 2007 compared to approximately $2.8 million in the same period last year.  For the year ended December 31, 2007, total revenues increased 106% to approximately $23.5 million compared to approximately $11.4 million in the prior year.

- Company reports Q3 profit of $188 thousand, or $0.01 per share -

DALLAS, TX – November 12, 2007 -- American CareSource Holdings, Inc. (AMEX: XSI) today announced financial and operational results for the third quarter and nine months ended September 30, 2007. Highlights include:

Dallas, TX, November 1, 2007 – American CareSource Holdings, Inc. (AMEX: XSI) announced today that it will hold a conference call on November 12, 2007 to discuss financial results of the three- and nine- months period ended September 30, 2007. David S. Boone, Chief Executive Officer, and Steven J. Armond, Chief Financial Officer, of American CareSource will host the call.
Access information

Date: Monday, November 12, 2007

Time: 10:00 am (CT)/11:00 am (ET)

Dial-in numbers: 888-812-8518 ( & ) or 913-312-1488

Live webcast: here

Dallas, TX - October 29, 2007 - American CareSource Holdings, Inc. (AMEX: XSI) announced today that its Chief Executive Officer, David S. Boone, will present at the CIBC World Markets 18th Annual Healthcare Conference. The presentation will be held on November 5, 2007 at 10:20 a.m. ET at the Waldorf-Astoria in New York City.

DALLAS, TX – October 25, 2007 -- American CareSource Holdings, Inc. (AMEX: XSI) today announced that Steven J. Armond has joined the Company as Chief Financial Officer, effective immediately. In this position, Mr. Armond, 39, will be responsible for the development and execution of financial strategy, business planning and analysis, accounting and administrative functions of the Company.

DALLAS, TX – October 15, 2007 -- American CareSource Holdings, Inc. (AMEX: XSI) today reported revenues of $7,088,000 for the third quarter ended September 30, 2007, a 114% increase compared to $3,313,000 in the same period last year.  The Company’s third quarter revenues also represent a 77% improvement over second quarter 2007 reported revenues of $4,008,000.

DALLAS, TX – September 26, 2007 -- American CareSource Holdings, Inc. (AMEX:XSI) announced today that David S. Boone has been promoted to the position of Chief Executive Officer of the Company, effective immediately. Mr. Boone had previously served as Chief Operational Officer and Chief Financial Officer of American CareSource, and will retain the title of Chief Financial Officer until a replacement is appointed.

American CareSource Holdings, Inc. (AMEX: XSI) announced today that its Chief Operational Officer and Chief Financial Officer, David S. Boone, will present at the Noble Financial Double-O-Seven Conference at 12:00 p.m. ET on August 21, 2007 at the Charleston Place Hotel in Charleston, South Carolina.

Dallas, TX, December 21, 2006--American CareSource Holdings, Inc. (AMEX: XSI) announced today that its Ancillary Care Services subsidiary has expanded its existing relationship with HealthSmart Preferred Care (HSPC) to include American Administrative Group (AAG).  Both HealthSmart Preferred Care and American Administrative Group are wholly owned subsidiaries of The Parker Group.  HealthSmart Preferred Care has been a client of American CareSource Holdings, Inc. since December 2005.

This expansion will provide American Administrative Group‘s payor clients with access to the extensive Ancillary Care Services network of providers that offer attractive rates on a wide spectrum of ancillary care services.  The company expects that this new relationship will substantially increase claim volume to the company.  Based on initial analytics, the company estimates that this expansion will at minimum increase annual revenue by $8-$12 million dollars once it has been fully implemented. The company expects to begin implementation and recognize revenue within the first quarter of 2007.

Irving, TX, August 11, 2006 – American CareSource Holdings, Inc. (OTCBB: ACSH.OB) today announced financial results for the quarter and six months ended June 30, 2006.

Irving, TX , August 11, 2006--American CareSource Holdings, Inc. (OTCBB: ACSH.OB) announced today that it has signed a Letter of Agreement to expand its existing relationship with ppoNEXT, Inc. that could add $12-$16 million in additional revenue once the implementation process is complete.  American CareSource generated approximately $815,000 in revenue from ppoNEXT, Inc. in 2005.  ppoNEXT, Inc. has been an active client since 2002.

Irving, TX, May 15, 2006 – American CareSource Holdings, Inc. (OTCBB: ACSH) today announced financial results quarter ended March 31, 2006.

IRVING, Texas, March 15 /PRNewswire-FirstCall/ -- American CareSource Holdings, Inc. (OTC Bulletin Board: ACSH - News) today announced that, effective March 1, 2006, James V. O'Rourke has been appointed to the position of Vice President Sales, National Accounts. In this newly created position, Mr. O'Rourke will focus on his existing relationships with third party administrators (TPA) and provide them with the value proposition ACS holds in reducing ancillary care benefit costs. He will report directly to Wayne A. Schellhammer, Chairman and Chief Executive Officer of American CareSource.

IRVING, Texas, March 2 /PRNewswire-FirstCall/ -- American CareSource Holdings, Inc. (OTC Bulletin Board: ACSH - News) a healthcare services company today announced it has raised an additional $2.7 million in gross proceeds from the sale of common stock.

IRVING, Texas, Feb. 17 /PRNewswire-FirstCall/ -- American CareSource Holdings, Inc. (OTC Bulletin Board: ACSH.OB - News) a healthcare services company today announced that it has raised $7.3 million in gross proceeds from the sale of common stock to institutional and accredited investors.